Difference between revisions of "Combining-Risperidone-Lamotrigine"

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* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
 
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
 
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
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* A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref>
 
* A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref>
 
* Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy.  <ref name="drugscom">
 
* Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy.  <ref name="drugscom">
{{Drugscominteract|risperidone-with-lamotrigine-1744-0-2286-0|risperidone|lamotrigine}}</ref>
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{{Drugscominteract|risperidone-with-lamotrigine-1430-848-2019-1305|risperidone|lamotrigine}}</ref>
 
}}
 
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Latest revision as of 08:13, 22 April 2010

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to risperidone.

Infobord.png General information
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start lamotrigine
  • Start lamotrigine according to the general dosing advice.
Letopbord.png Cave
  • A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. [7]
  • Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. [6]


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Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the risperidone dosage adjusted as necessary.