Difference between revisions of "Combining-Olanzapine-Gabapentin"
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| − | + | * This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. | |
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| − | * This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. | ||
| start = | | start = | ||
* Start gabapentine according to the general dosing advice. | * Start gabapentine according to the general dosing advice. | ||
| cave = | | cave = | ||
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom"> | * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom"> | ||
| − | {{Drugscominteract|olanzapine-with-gabapentin|olanzapine|gabapentin}}</ref> | + | {{Drugscominteract|olanzapine-with-gabapentin-1147-0-1744-1113|olanzapine|gabapentin}}</ref> |
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Latest revision as of 08:21, 22 April 2010
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Adding gabapentin to olanzapine.
General information- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
Start gabapentin- Start gabapentine according to the general dosing advice.
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [5]
- ↑ 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Farmacotherapeutisch Kompas - gabapentine (dutch)
- ↑ Interactions between olanzapine and gabapentin on drugs.com
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