Difference between revisions of "Combining-Gabapentin-Valproic acid"
From Psychiatrienet
(Created page with '{{Drugcombi | base = gabapentin | add = valproic acid | info = * Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted ...') |
|||
| (3 intermediate revisions by the same user not shown) | |||
| Line 3: | Line 3: | ||
| add = valproic acid | | add = valproic acid | ||
| info = | | info = | ||
| − | * | + | * {{CombiNoInteraction}} |
| − | |||
| − | |||
| start = | | start = | ||
* Start valproic acid according to the general dosing advice. | * Start valproic acid according to the general dosing advice. | ||
| cave = | | cave = | ||
}} | }} | ||
Latest revision as of 09:51, 23 April 2010
| ||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||
Adding valproic acid to gabapentin.
General information- Gabapentin is eliminated unchanged by the kidney for 100%.
- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [4]
Start valproic acid- Start valproic acid according to the general dosing advice.
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas - gabapentine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "valproaat" (Dutch)
- ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
