Combining-Ziprasidone-Gabapentin

Ziprasidone Type Antipsychotic Group Atypical AP Other use Moodstabilizer links Medscape Ziprasidone PubChem 60854 PubMed Ziprasidone Wikipedia Ziprasidone more info

Gabapentin Type moodstabilizer Group anticonvulsant links ATC-code N03AX12 PubChem 3446 PubMed Gabapentin Drugs.com gabapentin Kompas (Dutch) Gabapentin Wikipedia Gabapentin more info T1/2 5-7h bioavailability 60% administration O

Adding gabapentin to ziprasidone.

General information

• Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
• Gabapentin is eliminated unchanged by the kidney for 100%.
• Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
• This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.

Start gabapentin

• Start gabapentin according to the general dosing advice.

Cave

• Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.

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