Combining-Ziprasidone-Lithium

Ziprasidone Type Antipsychotic Group Atypical AP Other use Moodstabilizer links Medscape Ziprasidone PubChem 60854 PubMed Ziprasidone Wikipedia Ziprasidone more info

Lithium Type moodstabilizer Group other links ATC-code N05AN01 Medscape Lithium PubChem 11125 PubMed Lithium Drugs.com lithium Kompas (Dutch) Lithium Wikipedia Lithium more info T1/2 12-48h administration O

Adding lithium to Ziprasidone.

General information

• Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
• Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
• Ziprasidone is principally metabolized by CYP2D6 to an active metabolite.

Start lithium

• Start lithium according to the general dosing advice.

Cave

• The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.

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