Difference between revisions of "Fluoxetine-bupropion"
From Psychiatrienet
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* Bupropion inhibits CYP2D6 which metabolizes fluoxetine. | * Bupropion inhibits CYP2D6 which metabolizes fluoxetine. | ||
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks. | * Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks. | ||
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Revision as of 11:49, 21 October 2015
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Switch medication from fluoxetine to bupropion.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start bupropion- Day 1-28: administration of bupropion in a low dosage of 150 mg/day.
- Day 29 and on: if necessary increase bupropion to 300 mg/day.
More information- Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
- Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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