Difference between revisions of "Citalopram-fluvoxamine"

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| from = citalopram
 
| from = citalopram
 
| to = fluvoxamine
 
| to = fluvoxamine
| stop =  
+
| stop = {{StopCitalopram}}
* Gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
 
* When a dosage of 20 mg/day, resp. 10 mg/day, is reached, stop administration.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.
 
* No wash-out period is needed.
* Start fluvoxamine the next day in normal dosage of 50 mg/day.
+
* ''' Day 9: ''' start fluvoxamine in normal dosage of 50 mg/day.
 
| info =  
 
| info =  
* The same applies to [[escitalopram]].
 
 
* {{theorSS}}
 
* {{theorSS}}
* Fluvoxamine slows the metabolism of (es)citalopram by inhibition of CYP2C19 and CYP3A4
+
* Fluvoxamine slows the metabolism of citalopram by inhibition of CYP2C19 and CYP3A4
 
}}
 
}}

Latest revision as of 08:58, 28 October 2015

Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from citalopram to fluvoxamine.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Before day 1: gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of citalopram to a maximum of 10 mg/day.
  • Day 8: stop administration of citalopram
Eenrichtingbord.png Start fluvoxamine
  • No wash-out period is needed.
  • Day 9: start fluvoxamine in normal dosage of 50 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Fluvoxamine slows the metabolism of citalopram by inhibition of CYP2C19 and CYP3A4
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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