Difference between revisions of "Citalopram-fluvoxamine"
From Psychiatrienet
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| from = citalopram | | from = citalopram | ||
| to = fluvoxamine | | to = fluvoxamine | ||
| − | | stop = | + | | stop = {{StopCitalopram}} |
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| start = | | start = | ||
* No wash-out period is needed. | * No wash-out period is needed. | ||
| − | * | + | * ''' Day 9: ''' start fluvoxamine in normal dosage of 50 mg/day. |
| info = | | info = | ||
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* {{theorSS}} | * {{theorSS}} | ||
| − | * Fluvoxamine slows the metabolism of | + | * Fluvoxamine slows the metabolism of citalopram by inhibition of CYP2C19 and CYP3A4 |
}} | }} | ||
Latest revision as of 08:58, 28 October 2015
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Switch medication from citalopram to fluvoxamine.[1] [2]
Stop citalopram - Before day 1: gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of citalopram to a maximum of 10 mg/day.
- Day 8: stop administration of citalopram
Start fluvoxamine- No wash-out period is needed.
- Day 9: start fluvoxamine in normal dosage of 50 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluvoxamine slows the metabolism of citalopram by inhibition of CYP2C19 and CYP3A4
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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