Difference between revisions of "Maprotiline-duloxetine"

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Duloxetine is a inhibitor of CYP2D6, which metabolizes maprotiline.}}
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* Duloxetine is a inhibitor of CYP2D6, which metabolizes maprotiline.
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Revision as of 12:35, 2 November 2015

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from maprotiline to duloxetine.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Before day 1: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
  • Day 1: reduce dosage of maprotiline to 50 mg/day.
  • Day 7: reduce dosage of maprotiline to 25 mg/day.
  • Day 14: stop dosage of maprotiline.
Eenrichtingbord.png Start duloxetine
  • Day 7: simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
  • Day 14: stop administration of maprotiline and continue administration of duloxetine.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • Duloxetine is a inhibitor of CYP2D6, which metabolizes maprotiline.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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