Difference between revisions of "Doxepine-moclobemide"

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| to = moclobemide  
 
| to = moclobemide  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
+
{{Generaldecrease25p3d}}
* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.
+
{{7dWashout}}
* '''Day 8:''' reduce dosage of doxepin to 25 mg/day.
 
* '''Day 15:''' stop administration of doxepin.
 
 
| start =  
 
| start =  
* '''Day 15-28:''' a wash-out period of 2 weeks is necessary.
+
{{MAOIncrease25p}}
* '''Day 29''' start administration of moclobemide in a dosage of 150 mg/day.
 
* '''Day 35:''' increase dosage of moclobemide to 300 mg/day.
 
 
| caveat =
 
| caveat =
 
{{caveSS}}
 
{{caveSS}}
 
}}
 
}}

Latest revision as of 13:32, 16 June 2016

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from doxepin to moclobemide.[2] [3]

Nietinrijdenbord.png Stop doxepin
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait 7 days for washout
Eenrichtingbord.png Start moclobemide
  • Start at the first day after the washout period with about 25% of target dose.
Letopbord.png Cave


  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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