Difference between revisions of "Amitriptyline-bupropion"
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| − | * '''Day | + | * '''Day 8:''' start administration of bupropion in a dosage of 150 mg/day. |
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| − | * Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline. | + | * Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline. |
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Latest revision as of 15:55, 28 October 2015
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Switch medication from amitriptyline to bupropion.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of amitriptyline to 50 mg/day.
- Day 8: reduce dosage of amitriptyline to 25 mg/day.
- Day 15: stop administration of amitriptyline.
Start bupropion- Day 8: start administration of bupropion in a dosage of 150 mg/day.
More information- Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
- The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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