Difference between revisions of "Mirtazapine-hypericum"
From Psychiatrienet
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* '''Day 8-14:''' a wash-out period of one week is necessary. | * '''Day 8-14:''' a wash-out period of one week is necessary. | ||
* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day). | * '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day). | ||
| info = | | info = | ||
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| − | * Hypericum slows the metabolism of mirtazapine via CYP3A4. }} | + | * Hypericum slows the metabolism of mirtazapine via CYP3A4. |
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Latest revision as of 13:23, 7 October 2015
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Switch medication from mirtazapine to hypericum.[1] [2]
Stop mirtazapine - Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start hypericum- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
More information- Occurrence of the serotonin syndrome is possible without wash-out period.
- Hypericum slows the metabolism of mirtazapine via CYP3A4.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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