Difference between revisions of "Nortriptyline-sertraline"

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| to = sertraline  
 
| to = sertraline  
 
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* '''Before day 1:''' gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.
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{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of nortriptyline to 50 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of nortriptyline to 25 mg/day.
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| info =
| start =  
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* Safe target dose sertraline = 50 mg
* '''Day 1:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.
 
* '''Day 8:''' stop administration of nortriptyline and continue administration of sertraline in a dosage of 50-100 mg/day.
 
| info =
 
* Sertraline is a weak inhibitor of [[:wp:CYP2D6|CYP2D6]], which metabolizes nortriptyline. 
 
 
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Latest revision as of 11:52, 30 June 2023

Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from nortriptyline to sertraline.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start sertraline
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose sertraline = 50 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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