Difference between revisions of "Paroxetine-agomelatine"
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| from = paroxetine | | from = paroxetine | ||
| to = agomelatine | | to = agomelatine | ||
| stop = | | stop = | ||
| − | + | * '''Day 1:''' Decrease with about 25% of original dose every 3-4 days | |
| start = | | start = | ||
| − | + | {{startAgomelatine}} | |
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| info = | | info = | ||
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| − | + | {{SSRI14d}} | |
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Latest revision as of 12:06, 4 August 2023
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Switch medication from paroxetine to agomelatine.[1] [2] [3]
Stop paroxetine - Day 1: Decrease with about 25% of original dose every 3-4 days
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[4]
- If necessary, increase dosage of agomelatine to 50 mg/day.
More information- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ CBG meb, accessed august 2023,SmPC Valdoxan
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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