Difference between revisions of "Mianserine-duloxetine"
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| to = duloxetine | | to = duloxetine | ||
| stop = | | stop = | ||
| − | * ''' | + | * '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day. |
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day. | * '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day. | ||
| start = | | start = | ||
* '''Day 1:''' simultaneously start duloxetine in a low dosage of 30 mg/day. | * '''Day 1:''' simultaneously start duloxetine in a low dosage of 30 mg/day. | ||
| − | * '''Day 8:''' stop administration of mianserine and only continue administration of duloxetine. | + | * '''Day 8:''' stop administration of mianserine and only continue administration of duloxetine in a dosage of 60 mg/day. |
* If necessary, increase the dosage of duloxetine. | * If necessary, increase the dosage of duloxetine. | ||
| info = | | info = | ||
* Caution with this switch is necessary, because duloxetine slows the metabolism of mianserine via CYP2D6. }} | * Caution with this switch is necessary, because duloxetine slows the metabolism of mianserine via CYP2D6. }} | ||
Latest revision as of 15:09, 17 November 2009
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Switch medication from mianserine to duloxetine.[1] [2]
Stop mianserine - Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Start duloxetine- Day 1: simultaneously start duloxetine in a low dosage of 30 mg/day.
- Day 8: stop administration of mianserine and only continue administration of duloxetine in a dosage of 60 mg/day.
- If necessary, increase the dosage of duloxetine.
More information- Caution with this switch is necessary, because duloxetine slows the metabolism of mianserine via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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