Difference between revisions of "Fluoxetine-paroxetine"
From Psychiatrienet
| Line 13: | Line 13: | ||
* {{theorSS}} | * {{theorSS}} | ||
* Fluoxetine and norfluoxetine inhibit de metabolism of paroxetine via CYP2D6 | * Fluoxetine and norfluoxetine inhibit de metabolism of paroxetine via CYP2D6 | ||
| − | * Paroxetine | + | * Paroxetine inhibits the metabolism of fluoxetine via CYP2D6 |
}} | }} | ||
Revision as of 09:34, 31 December 2009
| ||||||||||||||||||||||
| ||||||||||||||||||||||
Switch medication from fluoxetine to paroxetine.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start paroxetineNo wash-out period is needed.
- Day 1: start paroxetine the next day in low dosage of 10 mg/day.
- Day 14: increase dosage of paroxetine to 20 mg/day.
More information- Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine and norfluoxetine inhibit de metabolism of paroxetine via CYP2D6
- Paroxetine inhibits the metabolism of fluoxetine via CYP2D6
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
