Difference between revisions of "Nortriptyline-escitalopram"
From Psychiatrienet
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* '''Day 1:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day. | * '''Day 1:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day. | ||
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| − | * Escitalopram is a weak inhibitor of CYP2D6, which metabolizes nortriptyline. | + | * Escitalopram is a very weak inhibitor of CYP2D6, which metabolizes nortriptyline. |
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Revision as of 16:03, 9 March 2010
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Switch medication from nortriptyline to escitalopram.[1] [2]
Stop nortriptyline - Before day 1: gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.
- Day 1: reduce dosage of nortriptyline to 50 mg/day.
- Day 3: reduce dosage of nortriptyline to 25 mg/day.
- Day 8: stop administration of nortriptyline.
Start escitalopram- Day 1: simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
More information- Escitalopram is a very weak inhibitor of CYP2D6, which metabolizes nortriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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