Difference between revisions of "Combining-Valproic acid-Quetiapine"
From Psychiatrienet
Line 10: | Line 10: | ||
| cave = | | cave = | ||
* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscom"> | * During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscom"> | ||
− | {{Drugscominteract|quetiapine-with-valproic-acid|quetiapine|valproic acid}}</ref> | + | {{Drugscominteract|quetiapine-with-valproic-acid-1979-1274-2286-0|quetiapine|valproic acid}}</ref> |
}} | }} |
Revision as of 20:58, 8 March 2010
| ||||||||||||||||||||||||||||||||||||||||||
|
Adding quetiapine to valproic acid.
- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. [6]
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - valproinezuur (dutch)
- ↑ 3.0 3.1 3.2 3.3 KNMP; Informatorium Medicamentorum 2023; Monografie "valproaat" (Dutch)
Cite error: Invalid
<ref>
tag; name "informatorium" defined multiple times with different content - ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 6.0 6.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>
tag; name "drugscom" defined multiple times with different content
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.