Difference between revisions of "Combining-Quetiapine-Lithium"
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* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscom"> | * During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscom"> | ||
| − | {{Drugscominteract|quetiapine-with-lithium|quetiapine|lithium}}</ref> | + | {{Drugscominteract|quetiapine-with-lithium/1477-0-1979-1274|quetiapine|lithium}}</ref> |
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Revision as of 19:51, 9 March 2010
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General information- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
lithium
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. [5]
Start quetiapine- Start lithium according to the general dosing advice.
Cave- During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. [4]
- ↑ 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content - ↑ Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24
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