Difference between revisions of "Bupropion-doxepine"
From Psychiatrienet
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| to = doxepin | | to = doxepin | ||
| stop = | | stop = | ||
| − | * Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. | + | * '''Before day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. |
| − | * | + | * '''Day 1:''' Stop administration of bupropion |
| start = | | start = | ||
* '''Day 1-3:''' start administration of doxepin the next day in a low dosage of 25 mg/day. | * '''Day 1-3:''' start administration of doxepin the next day in a low dosage of 25 mg/day. | ||
Revision as of 14:36, 27 November 2009
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Switch medication from bupropion to doxepin.[2] [3]
Stop bupropion - Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- Day 1: Stop administration of bupropion
Start doxepin- Day 1-3: start administration of doxepin the next day in a low dosage of 25 mg/day.
- Day 4: increase dosage of doxepin to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information- Bupropion slows the metabolism of doxepin via CYP2D6.
- Caution is necessary at the start of administration of doxepin.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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