SwitchAntipsychotics

Switching Antipsychotics

To see the consequences of a switch between antipsychotics click in the crosstable below: the switch is made "from" (vertical) "to" (horizontal).
During switching: don't reduce anticholinergics; consider adding oxazepam. Read: General considerations concerning switching antipsychotics.

Rest AP = Chlorprothixene, Flupentixol, Fluphenazine Loxapine, Pericyazine, Perphenazine,Promazine, Trifluoperazine, Ziprasidone, Zuclopentixol.

Partial agonist new = Aripiprazole, Brexpiprazole, Cariprazine.

↓ from	to →	Am	Cp	Hp	Lu	Ol	Pp	Pa	Pi	Pf	Qu	Rd	Sd	Sr	RA	Da	Df	Di	Dh	Do	Dp	Dr	Dz	Mz
Am	Amisulpride	—	AmCp	AmHp	AmLu	AmOl	AmPp	AmPa	AmPi	AmPf	AmQu	AmRd	AmSd	AmSr	AmRA	—	—	—	—	—	—	—	—	AmMz
Cp	Clozapine	CpAm	—	CpHp	CpLu	CpOl	CpPp	CpPa	CpPi	CpPf	CpQu	CpRd	CpSd	CpSr	CpRA	—	—	—	—	—	—	—	—	CpMz
Hp	Haloperidol	HpAm	HpCp	—	HpLu	HpOl	HpPp	HpPa	HpPi	HpPf	HpQu	HpRd	HpSd	HpSr	HpRA	—	—	—	HpDh	—	—	—	—	HpMz
Lu	Lurasidone	LuAm	LuCp	LuHp	—	LuOl	LuPp	LuPa	LuPi	LuPf	LuQu	LuRd	LuSd	LuSr	LuRA	—	—	—	—	—	—	—	—	LuMz
Ol	Olanzapine	OlAm	OlCp	OlHp	OlLu	—	OlPp	OlPa	OlPi	OlPf	OlQu	OlRd	OlSd	OlSr	OlRA	—	—	—	—	OlDo	—	—	—	OlMz
Pp	Paliperidone	PpAm	PpCp	PpHp	PpLu	PpOl	—	PpPa	PpPi	PpPf	PpQu	PpRd	PpSd	PpSr	PpRA	—	—	—	—	—	PpDp	PpDr	—	PpMz
Pa	Partial agonist	PaAm	PaCp	PaHp	PaLu	PaOl	PaPp	PaPa	PaPi	PaPf	PaQu	PaRd	PaSd	PaSr	PaRA	PaDa	—	—	—	—	—	—	—	PaMz
Pi	Pimozide	PiAm	PiCp	PiHp	PiLu	PiOl	PiPp	PiPa	—	PiPf	PiQu	PiRd	PiSd	PiSr	PiRA	—	—	—	—	—	—	—	—	PiMz
Pf	Penfluridol	PfAm	PfCp	PfHp	PfLu	PfOl	PfPp	PfPa	PfPi	—	PfQu	PfRd	PfSd	PfSr	PfRA	—	—	—	—	—	—	—	—	PfMz
Qu	Quetiapine	QuAm	QuCp	QuHp	QuLu	QuOl	QuPp	QuPa	QuPi	QuPf	—	QuRd	QuSd	QuSr	QuRA	—	—	—	—	—	—	—	—	QuMz
Rd	Risperidone	RdAm	RdCp	RdHp	RdLu	RdOl	RdPp	RdPa	RdPi	RdPf	RdQu	—	RdSd	RdSr	RdRA	—	—	—	—	—	RdDp	RdDr	—	RdMz
Sd	Sertindole	SdAm	SdCp	SdHp	SdLu	SdOl	SdPp	SdPa	SdPi	SdPf	SdQu	SdRd	—	SdSr	SdRA	—	—	—	—	—	—	—	—	SdMz
Sr	Sulpiride	SrAm	SrCp	SrHp	SrLu	SrOl	SrPp	SrPa	SrPi	SrPf	SrQu	SrRd	SrSd	—	SrRA	—	—	—	—	—	—	—	—	SrMz
RA	Rest AP	RAAm	RACp	RAHp	RALu	RAOl	RAPp	RAPa	RAPi	RAPf	RAQu	RARd	RASd	RASr	RARA	—	RADf	RADi	—	—	—	—	RADz	RAMz
Da	Aripiprazole_LA	DaAm	DaCp	DaHp	DaLu	DaOl	DaPp	DaPa	DaPi	DaPf	DaQu	DaRd	DaSd	DaSr	DaRA	—	—	—	—	—	—	—	—	DaMz
Df	Fluphenazine_LA	DfAm	DfCp	DfHp	DfLu	DfOl	DfPp	DfPa	DfPi	DfPf	DfQu	DfRd	DfSd	DfSr	DfRA	—	—	—	—	—	—	—	—	DfMz
Di	Flupenthixol_LA	DiAm	DiCp	DiHp	DiLu	DiOl	DiPp	DiPa	DiPi	DiPf	DiQu	DiRd	DiSd	DiSr	DiRA	—	—	—	—	—	—	—	—	DiMz
Dh	Haloperidol_LA	DhAm	DhCp	DhHp	DhLu	DhOl	DhPp	DhPa	DhPi	DhPf	DhQu	DhRd	DhSd	DhSr	DhRA	—	—	—	—	—	—	—	—	DhMz
Do	Olanzapine_LA	DoAm	DoCp	DoHp	DoLu	DoOl	DoPp	DoPa	DoPi	DoPf	DoQu	DoRd	DoSd	DoSr	DoRA	—	—	—	—	—	—	—	—	DoMz
Dp	Paliperidone_ER	DpAm	DpCp	DpHp	DpLu	DpOl	DpPp	DpPa	DpPi	DpPf	DpQu	DpRd	DpSd	DpSr	DpRA	—	—	—	—	—	DpDp	DpDr	—	DpMz
Dr	Risperidone_LA	DrAm	DrCp	DrHp	DrLu	DrOl	DrPp	DrPa	DrPi	DrPf	DrQu	DrRd	DrSd	DrSr	DrRA	—	—	—	—	—	DrDp	—	—	DrMz
Dz	Zuclopenthixol_LA	DzAm	DzCp	DzHp	DzLu	DzOl	DzPp	DzPa	DzPi	DzPf	DzQu	DzRd	DzSd	DzSr	DzRA	—	—	—	—	—	—	—	—	DzMz
Mz	Zuclopenthixol_MA	MzAm	MzCp	MzHp	MzLu	MzOl	MzPp	MzPa	MzPi	MzPf	MzQu	MzRd	MzSd	MzSr	MzRA	—	—	—	—	—	—	—	MzDz	—

ER = extended release (long + super + ultra long acting), LA = long acting, MA = medium acting, UC = under construction