Difference between revisions of "Venlafaxine-agomelatine"

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* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
 
* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
 
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
 
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
 
+
* '''Day 8:''' stop administration of venlafaxine
  
 
| start =  
 
| start =  
* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.  
+
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.  
* '''Day 8:''' stop administration of venlafaxine and continue administration of amitriptyline in a dosage of 50 mg/day.
+
* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
 
 
 
 
| info =
 
* “Start low, go slow” for amitriptyline, and caution with this switch is necessary.
 
* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes amitriptyline.}}
 

Revision as of 10:58, 5 June 2009

{{Drugswitch | from = venlafaxine | to = agomelatine | stop =

  • Day 0: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
  • Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
  • Day 8: stop administration of venlafaxine

| start =

  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
  • Day 8: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.