Difference between revisions of "Clomipramine-fluoxetine"
From Psychiatrienet
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
| − | * Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize clomipramine. | + | * Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize clomipramine. |
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Revision as of 14:19, 16 September 2009
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Switch medication from clomipramine to fluoxetine.[1] [2]
Stop clomipramine - Before day 1: gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
- Day 1: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop dosage of clomipramine.
Start fluoxetine- Day 8: start administration of fluoxetine in a normal dosage of 20 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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