Difference between revisions of "Agomelatine-fluvoxamine"
From Psychiatrienet
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| − | * Fluvoxamine stops the metabolism of agomelatine via CYP1A2 and CYP2C9.}} | + | * Fluvoxamine stops the metabolism of agomelatine via CYP1A2 and CYP2C9. |
| + | <ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref> | ||
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Revision as of 11:51, 5 March 2010
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Switch medication from agomelatine to fluvoxamine.[1] [2]
Stop agomelatine - Gradually reduce dosage of agomelatine to a maximum of 25 mg/day.
- When a dosage of 25 mg/day is reached , stop administration.
Start fluvoxamine- A wash-out period of one day is necessary.
- Start administration of fluvoxamine the next day in a normal dosage of 50 mg/day.
More information- Fluvoxamine stops the metabolism of agomelatine via CYP1A2 and CYP2C9.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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