Difference between revisions of "Combining-Carbamazepine-Gabapentin"
From Psychiatrienet
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* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases. | * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases. | ||
* Gabapentine is eliminated unchanged by the kidney for 100%. | * Gabapentine is eliminated unchanged by the kidney for 100%. | ||
| − | * {{ | + | * {{CombiNoInteraction} |
| start = | | start = | ||
* Start gabapentine according to the general dosing advice. | * Start gabapentine according to the general dosing advice. | ||
Revision as of 12:24, 21 April 2010
{{Drugcombi | base = carbamazepine | add = gabapentin | info =
- Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
- Gabapentine is eliminated unchanged by the kidney for 100%.
- {{CombiNoInteraction}
| start =
- Start gabapentine according to the general dosing advice.
| cave =
- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [1]
}}
