Difference between revisions of "Combining-Gabapentin-Lamotrigine"
From Psychiatrienet
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* Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects. | * Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects. | ||
* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases. | * Lamotrigine is principally metabolised by UDP-glucuronosyltransferases. | ||
| − | * {{ | + | * {{CombiNoInteraction}} |
| start = | | start = | ||
* Start lamotrigine according to the general dosing advice. | * Start lamotrigine according to the general dosing advice. | ||
| cave = | | cave = | ||
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Adding lamotrigine to gabapentin.
General information- Gabapentin is eliminated unchanged by the kidney for 100%.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [4]
Start lamotrigine- Start lamotrigine according to the general dosing advice.
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas - gabapentine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Drugs.com lamotrigine
- ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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