Difference between revisions of "Combining-Aripiprazole-Topiramate"
From Psychiatrienet
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| add = topiramate | | add = topiramate | ||
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| − | * This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects | + | * This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. |
| start = | | start = | ||
* Start topiramate according general dosing advice. | * Start topiramate according general dosing advice. | ||
| + | * Dose adaptation of aripiprazole could be necessary because of the enzym induction by topiramate. | ||
| cave = | | cave = | ||
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">{{Drugscominteract|aripiprazole-with-topiramate-233-0-2216-0|aripiprazole|topiramate}}</ref> | * Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">{{Drugscominteract|aripiprazole-with-topiramate-233-0-2216-0|aripiprazole|topiramate}}</ref> | ||
* Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather. | * Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather. | ||
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Latest revision as of 12:01, 18 June 2010
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Adding topiramate to aripiprazole.
General information- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.
Start topiramate- Start topiramate according general dosing advice.
- Dose adaptation of aripiprazole could be necessary because of the enzym induction by topiramate.
Cave- Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [2]
- Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.
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