Difference between revisions of "Quetiapine-Lurasidone"

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| from = Quetiapine
 
| from = Quetiapine
 
| to = Lurasidon
 
| to = Lurasidon
| stop =  
+
| stop = {{StopStand}}
* '''Day 1-7:''' gradually reduce the dose of quetiapine to 50% of the dose.
+
| start = {{StartStand}}
* '''Day 8-14:''' gradually reduce the dose of queatipne to 0% of the dose
+
| info =  
* '''Day 14:''' stop administration of quetiapine.
+
{{RefSwitchToLurasidone}}
| start =  
+
| view = switchstandaardup en down.jpg
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
 
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable. 
 
| info = {{caveQT}}
 
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
 
 
}}
 
}}

Revision as of 14:31, 16 March 2015

Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Lurasidone
Type Antipsychotic
Group Atypical AP
links
Medscape Lurasidone
PubMed Lurasidone
Kompas (Dutch) Lurasidone
Wikipedia Lurasidone

Switch medication from Quetiapine to Lurasidon.[5] [6]

Nietinrijdenbord.png Stop Quetiapine
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Lurasidon
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
Infobord.png More information
  • More information on switching to lurasidon: see reference. [7]
    Switchstandaardup en down.jpg
Nietinrijdenbord.png — Quetiapine
Eenrichtingbord.png — Lurasidon


  1. 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 73 (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. Drugs.com quetiapine-fumarate
  5. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  6. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  7. McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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