Difference between revisions of "Fluoxetine-doxepine"
From Psychiatrienet
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* '''Day 15:''' increase dosage of doxepin to 50 mg/day. | * '''Day 15:''' increase dosage of doxepin to 50 mg/day. | ||
* '''Day 29:''' increase dosage of doxepin to 75 mg/day. | * '''Day 29:''' increase dosage of doxepin to 75 mg/day. | ||
| − | | info = | + | |
| + | |info = | ||
* Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6. | * Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6. | ||
{{longt1/2fluvox}} | {{longt1/2fluvox}} | ||
* Start low, go slow for doxepin. | * Start low, go slow for doxepin. | ||
Revision as of 13:43, 28 October 2015
{{Drugswitch | from = fluoxetine | to = doxepin | stop =
- Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
- Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
| start = Caution is necessary for at least four weeks.
- Day 2: start administration of doxepin in a low dosage of 25 mg/day.
- Day 15: increase dosage of doxepin to 50 mg/day.
- Day 29: increase dosage of doxepin to 75 mg/day.
|info =
- Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.
- Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
- Start low, go slow for doxepin.
