Stop-paroxetine

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paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine


Nietinrijdenbord.png Stop paroxetine
  • In general after long-term maintenance treatment, the best is to reduce the dose by about 25% every 4-6 weeks. An apt pharmaceutical dose (tablet, capsule, mixture) is not always available. In these cases one should be creative with dosing.[1][2]
  • Another, more risky, possibility is being at a certain dose to use the following scheme:
  • ≥ 30 mg/day [3]:
  • Day 1: reduce dosage of paroxetine to 20 mg/day.
  • Day 8: reduce dosage of paroxetine to 10 mg/day.
  • Day 15: reduce dosage of paroxetine to 5 mg/day in 2 doses.
  • Day 22: reduce dosage of paroxetine to 2,5 mg/day in 2 doses.
  • Day 29: stop administration of paroxetine.



  1. The UK Drug and Therapeutics Bulletin; 1999;37:49-52
  2. Editor: please note that not all dosages are available in pharmacy. So now and then you should be creative.
  3. [Moleman P, Geneesmiddelen voor de geest: een praktische gids. Amsterdam: Nieuwezijds; 2007. p.225.](dutch)
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