Stop-duloxetine

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Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine


Nietinrijdenbord.png Stop duloxetine
  • In general after long-term maintenance treatment, the best is to reduce the dose by about 25% every 4-6 weeks. An apt pharmaceutical dose (tablet, capsule, mixture) is not always available. In these cases one should be creative with dosing.[1][2]
  • Another, more risky, possibility is being at a certain dose to use the following scheme:
  • 120 mg/day:
  • Day 1: reduce dosage of duloxetine to 90 mg/day.
  • Day 8: reduce dosage of duloxetine to 60 mg/day.
  • Day 15: reduce dosage of duloxetine to 30 mg/day.
  • Day 22: stop administration of duloxetine.



  1. The UK Drug and Therapeutics Bulletin; 1999;37:49-52
  2. Editor: please note that not all dosages are available in pharmacy. So now and then you should be creative.
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