Combining-Olanzapine-Lamotrigine
From Psychiatrienet
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Adding lamotrigine to olanzapine.
General information- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start lamotrigine- Start lamotrigine according to the general dosing advice.
Cave- Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. [5]
- ↑ 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
- ↑ 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid
<ref>tag; name "ftktox" defined multiple times with different content - ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
- ↑ 5.0 5.1 Drugs.com lamotrigine Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content
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