Amitriptyline-bupropion

Amitriptyline Type Antidepressant Group TCA links ATC-code N06AA09 Medscape Amitriptyline PubChem 2160 PubMed Amitriptyline Kompas (Dutch) Amitriptyline Wikipedia Amitriptyline more info T1/2 48h administration O

Bupropion Type Antidepressant Group other links ATC-code N06AX12 Medscape Bupropion PubChem 444 PubMed Bupropion Kompas (Dutch) Bupropion Wikipedia Bupropion more info T1/2 24h administration O

Switch medication from amitriptyline to bupropion.

Stop amitriptyline

• Before day 1: if the dosage of this tricyclic antidepressant (TCA) is > 100 mg/day, gradually reduce by 50 mg per 3-4 days to a maximum of 100 mg/ day.
• Day 1-3: administer 75 mg/day.
• Day 4-6: administer 50 mg/day.
• Day 7-9: administer 25 mg/day.
• Day 10: stop administration.

Start bupropion

• Day 7: start administration of bupropion in a dosage of 150 mg/day.

More information

• Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
• The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
• The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
  

The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.