Trazodone-venlafaxine
From Psychiatrienet
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Switch medication from trazodone to venlafaxine.[1] [2]
Stop trazodone - Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 75-100 mg.
- Day 8: stop administration of trazodone.
Start venlafaxine- Day 8-13: a wash-out period of about one week is necessary.
- Day 14: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
More information- Occurrence of the serotonin syndrome is theoretically possible, so care is needed.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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