Combining-Topiramate-Ziprasidone

Topiramate Type moodstabilizer Group anticonvulsant links ATC-code N03AX11 PubChem 5284627 PubMed Topiramate Drugs.com topiramate Kompas (Dutch) Topiramate Wikipedia Topiramate more info T1/2 21h bioavailability 50% administration O

Ziprasidone Type Antipsychotic Group Atypical AP Other use Moodstabilizer links Medscape Ziprasidone PubChem 60854 PubMed Ziprasidone Wikipedia Ziprasidone more info

Adding ziprasidone to topiramate.

General information

• Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
• Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
• Ziprasidone is metabolized by CYP3A4 and CYP1A2 (minor).
• Dose adaptation will be recommended for this combination.
• This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.

Start ziprasidone

• Start ziprasidone according general dosing advice.

Cave

• Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity.

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