Combining-Lamotrigine-Olanzapine
From Psychiatrienet
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Adding olanzapine to lamotrigine.
General information- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start olanzapine- Start lamotrigine according to the general dosing advice.
Cave- Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. [3]
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
Cite error: Invalid
<ref>tag; name "ftktox" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
- ↑ 3.0 3.1 Drugs.com lamotrigine Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content - ↑ 4.0 4.1 4.2 4.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
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