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| stop = {{StopAgomelatine}}
| start =
* '''Day 2: '''Start administration of imipramine in a dosage of 25-75 mg/day.
* If necessary, gradually increase the dose with about 25% of the target dose every 3 days.
* Therapeutic Drug Monitoring of imipramine is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.
|info =
* A wash-out period is not necessary.
}}
