Changes

{[{Drugswitch

| stop = * Agomelatine can be stopped abruptly for every dosage.{{StopAgomelatine}}

* '''Day 2: '''Start administration of imipramine the next day in a dosage of 25-75 mg/day.* If necessary, gradually increase dosage the dose with about 25% of the target dose every 3 days. * Therapeutic Drug Monitoring of imipramine to 150is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week. |info =* A wash-200 mg/dayout period is not necessary. }}