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Combining-Gabapentin-Carbamazepine

467 bytes removed, 16:21, 23 April 2010
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| base = gabapentin
| add = carbamazepine
| info = * Gabapentine is eliminated unchanged by the kidney for 100%.* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases. * This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998&nbsp;155:12-21}}</ref>
| start =
* Start carbamazepine according to the general dosing advice.{{CombiCaGa}}
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|carbamazepine-with-gabapentinegabapentin-1147-0-497-0|carbamazepine|gabapentine}}</ref>
}}
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