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| from = duloxetine
| to = vortioxetine
| stop = * '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day{{StopSSRI, when this dosage is > 60 mg/day. * '''Day 1-7:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day* '''Day 8-14:''' reduce dosage of duloxetine to 30 mg/day to 0 mg/day* '''Day 15:''' stop administration of duloxetine. SNRI}}| start = * A wash-out period is not necessary, but care is needed.* '''Day 15:''' Start administration of vortioxetine in a dosage of 10 mg/day.{{StartAntidepressant}}
| info =
* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes Safe target dose vortioxetine. = 10 mg* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
}}
