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| from = duloxetine
| to = vortioxetine
| stop = * '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day{{StopSSRI, when this dosage is > 60 mg/day. * '''Day 1-7:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day* '''Day 8-14:''' reduce dosage of duloxetine to 30 mg/day to 0 mg/day* '''Day 15:''' stop administration of duloxetine. SNRI}}| start = * A wash-out period is not necessary, but care is needed.* '''Day 15:''' Start administration of vortioxetine in a dosage of 10 mg/day.{{StartAntidepressant}}
| info =
* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes Safe target dose vortioxetine. * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.= 10 mg* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>{{theorSS}}
}}
