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Fluvoxamine-doxepine

306 bytes removed, 15:40, 30 June 2023
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| from = fluvoxamine
| to = doxepin
| stop = * '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day. {{StopSSRI,SNRI}}
| start =
 * '''Day 1:''' simultaneously start administration of doxepin doxepine in a low dosage of 25 mg25mg/day. * '''Day 8:''' stop administration increase dosage of fluvoxamine and continue administration of doxepin only. If necessary, increase doxepine to a dosage of doxepin75 mg/day.
| info =
* Fluvoxamine is an inhibitor fluvoxamine slows the metabolism of CYP1A2, doxepine via CYP2C19 and CYP3A4 (moderate), which metabolize doxepininhibition.* "Start low, go slow" is not required, but caution is necessary.{{SSCYPinh}}* {{TCAplasmalevelmonitoring}}}}

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