624
edits
Changes
no edit summary
| from = fluvoxamine
| to = doxepin
| stop = {{stopFluvoxamineStopSSRI,SNRI}}
| start =
* '''Day 1:''' simultaneously start administration of doxepin doxepine in a low dosage of 25 mg25mg/day. * '''Day 8:''' stop administration increase dosage of fluvoxamine and continue administration of doxepin only. If necessary, increase doxepine to a dosage of doxepin75 mg/day.
| info =
* Fluvoxamine is an inhibitor fluvoxamine slows the metabolism of CYP1A2, doxepine via CYP2C19 and CYP3A4 (moderate), which metabolize doxepininhibition.* "Start low, go slow" is not required, but caution is necessary.{{SSCYPinh}}* {{TCAplasmalevelmonitoring}}
