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* '''Day 47:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of maprotiline according to the scheme above.* '''Day 814:''' stop administration of maprotiline and continue administration of bupropion.
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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes maprotiline.
* {{RiskSeizureBupropionTCA}}
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