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Maprotiline-bupropion

232 bytes removed, 16:16, 28 October 2015
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* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.* '''Day 1-3:''' reduce dosage of maprotiline to 50 mg/day.* '''Day 4-7:''' reduce dosage of maprotiline to 25 mg/day.{{stopMaprotiline}}
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* '''Day 47:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of maprotiline according to the scheme above.* '''Day 814:''' stop administration of maprotiline and continue administration of bupropion.
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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes maprotiline.
* {{RiskSeizureBupropionTCA}}
{{review}}
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