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* No wash-out period is needed.* '''Day 89:''' start administration of amitriptyline in a dosage of 25 mg/day. * '''Day 1516:''' continue administration of amitriptyline in a dosage of 50 mg/day. {{Day22NoBloodlevelvortioxetine}}<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
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* {{theorSS}}
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