Switch medication from vortioxetine to amitriptyline.
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
No wash-out period is needed.
- Day 9: start administration of amitriptyline in a dosage of 25 mg/day.
- Day 16: continue administration of amitriptyline in a dosage of 50 mg/day.
- Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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