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* '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day.
* '''Day 1:''' reduce dosage of clomipramine to 50 mg/day.
* '''Day 8:''' reduce dosage of clomipramineto clomipramine to 25 mg/day.* '''Day 15:''' stop administration of clomipramine.
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 15:''' stop administration of clomipramine and only continue administration of agomelatine.
* If necessary, increase dosage of agomelatine to 50 mg/day. }}
