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* '''Before day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
* '''Day 1:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day.
* '''Day 8:''' stop administration of duloxetine.
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 8:''' stop administration of duloxetine and only continue administration of agomelatine.* If necessary, increase dosage of agomelatine to 50 mg/day. }}
