* '''Before day 0:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day, resp. 10 mg/day. {{TCAdecrease25p3d}}* '''Day 1:''' reduce dosage of citalopram/escitalopram to 10 mg/day, resp. 5 mg/day.* '''Day 8:''' stop administration of citalopram/escitalopram.| start = {{StartAgomelatine}}* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}