838
edits
Changes
Created page with '{{ Drugswitch | from = trazodone | to = duloxetine | stop = * '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg...'
{{ Drugswitch
| from = trazodone
| to = duloxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary.
* '''Day 1:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
* '''Day 8:''' stop administration of trazodone and continue administration of duloxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Duloxetine is a weak inhibitor of CYP2D6, which metabolizes trazodone.}}
| from = trazodone
| to = duloxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary.
* '''Day 1:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
* '''Day 8:''' stop administration of trazodone and continue administration of duloxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Duloxetine is a weak inhibitor of CYP2D6, which metabolizes trazodone.}}
